Mouse Model

Adjacent to directly human related research, our laboratory is interested to uncover the mechanisms of sustained versus resolution of inflammation in murine models.
We are interested in various posttranslational modifications of proteins, such as phosphorylation, ubiquitination and their effect on the gene transcription factors, signal transduction that modulate cellular responses and cellular bioenergetics.

 
Talreja J, Bauerfeld C, Wang X, Hafner M, Liu Y, Samavati L. MKP-1 modulates ubiquitination/phosphorylation of TLR signaling. Life Sci Alliance. 2021 Sep 27;4(12):e202101137. doi: 10.26508/lsa.202101137. Print 2021 Dec. PMID: 34580177

Harvinder Talwar, Mohamad Bouhamdan, Christian Bauerfeld*, Jaya Talreja*, Rifdat Aoidi, Nicolas Houde, Jean Charron, and Lobelia Samavati. MEK2 negatively Regulates LPS Mediated IL-1βProduction Through HIF-1α Expression. Journal of immunology. 2019 Feb 1. pii: ji1801477. doi: 10.4049/jimmunol.1801477 Impact Factor: 5.2 Citations:7

Jaya Talreja* and Samavati L. K63-Linked Polyubiquitination on TRAF6 Regulates LPS-Mediated MAPK Activation, Cytokine Production, and Bacterial Clearance in Toll-Like Receptor 7/8 Primed Murine Macrophages. Front Immunol. 2018 Feb 21;9:279. doi: 10.3389/fimmu.2018.00279.

Kezhong Zhang; HuiLiu, Zhenfeng Song,Yuan yuan Jiang, HyunbaeKim, Lobelia Samavati, Hien M.Nguyen, Zeng-QuanYang. The UPR Transducer IRE1 Promotes Breast Cancer Malignancy by Degrading Tumor Suppressor microRNAs; iScience. 2020 Aug 25;23(9):101503. doi: 10.1016/j.isci.2020.101503. Online ahead of print.PMID: 32911332 

Samavati L, Lee I, Mathes I, Lottspeich F, and Hüttemann M. TNFα Inhibits Oxidative Phosphorylation through Tyrosine Phosphorylation at Subunit I of Cytochrome c Oxidase.  J Biol Chem 2008; 283:21134-44.