Jeffrey Tseng, PhD

Education

University of Illinois at Chicago, PhD, 2006

Research Focus

In our lab, we study protein structure, function, classification and evolution. We use geometric approaches to address biological and medical issues of protein and RNA structures in Structural Biology and Molecular Evolution. We design parallel algorithms to perform large-scale computations on these 3D structures via Beowulf Linux clusters.

Our research focuses on protein structure and function by using protein shape analysis. We are also interested in the areas of surface identification, characterization, and classification, geometric and evolutionary matching techniques, disease-associated non-synonymous single-nucleotide polymorphism (nsSNP), structural variations associated with gene duplication and Knot theory applied in RNA structures. Novel areas of research include the use of high-throughput computing technology for generating millions of surface patches to study protein-protein interactions and geometric modeling for drug discovery.

Mentoring

Accepting new M.S. students in 2024-2025

Accepting new Ph.D. students in 2024-2025

Recent Publications

     Tseng YY*, Sanders MA, Zhang H, Zhou L, Chou CY, Granneman JG*. Structural and functional insights into ABHD5, a ligand-regulated lipase co-activator. Sci Rep. 2022 Feb 16;12(1):2565. PubMed Central PMCID: PMC8850477.

     Wang B, Lei X, Tian W, Perez-Rathke A, Tseng YY*, Liang J*. Structure-based pathogenicity relationship identifier for predicting effects of single missense variants and discovery of higher-order cancer susceptibility clusters of mutations. Brief Bioinform. 2023 Jun 17; PubMed ID: 37332013.

     Bhattacharjee MJ, Lin JJ, Chang CY, Chiou YT, Li TN, Tai CW, Shiu TF, Chen CA, Chou CY, Chakraborty P, Tseng YY*, Wang LH*, Li WH*. Identifying Primate ACE2 Variants That Confer Resistance to SARS-CoV-2. Mol Biol Evol. 2021 Jun 25;38(7):2715-2731. PubMed Central PMCID: PMC7989403.

     Lin JJ, Bhattacharjee MJ, Yu CP, Tseng YY*, Li WH*. Many human RNA viruses show extraordinarily stringent selective constraints on protein evolution. Proc Natl Acad Sci U S A. 2019 Sep 17;116(38):19009-19018. PubMed Central PMCID: PMC6754614.

     Sanders MA, Zhang H, Mladenovic L, Tseng YY*, Granneman JG*. Molecular Basis of ABHD5 Lipolysis Activation. Sci Rep. 2017 Feb 17;7:42589. PubMed Central PMCID: PMC5314347.