Lawrence I. Grossman, PhD

Lawrence I. Grossman, PhD
Henry L. Brasza Professor of Molecular Medicine and Genetics
Director, Center for Molecular Medicine and Genetics
Professor of Internal Medicine
Scott Hall, Rm 3129
540 E. Canfield Avenue
Detroit, MI 48201
313-577-5326
l.grossman@wayne.edu

Education

Albert Einstein College of Medicine, PhD, 1971

Research Focus

We work on mitochondrial molecular genetics. Mitochondria are semi-autonomous organelles because they have their own DNA and genetic machinery but must cooperate with the nucleus to function. Mitochondria contain about 1500 proteins, most nucleus encoded, and carry out a number of functions, most centrally to provide most of the energy in the cell. So important is proper energy functionin that mitochondria turn out to be responsible for, or to be involved in, a growing array of diseases, including many common late onset diseases such as various peripheral neuropathies, cardiomyopathies, and type II diabetes. We are focusing increasingly on mitochondrial disease mechanisms, including genomic approaches to population disease susceptibilities. We are also interested in the evolutionary emergence of an enlarged neocortex, the most highly oxygen-utilizing tissue.

Laboratory Page

Recent Publications

  Kalpage HA, Wan J, Morse PT, Zurek MP, Turner AA, Khobeir A, Yazdi N, Hakim A, Liu J, Vaishnav A, Sanderson TH, Recanati M-A, Grossman LI, Lee I, Edwards BFP, Hüttemann M (2020). Cytochrome c phosphorylation: Control of mitochondrial electron transport chain flux and apoptosis. Int J Biochem Cell Biol, 121:105704. doi: 10.1016/j.biocel.2020.105704. PMID: 32023432.

 Hüttemann M, Sommer N, Weissmann N, Grossman LI (2019). Letter by Hüttemann et al Regarding Article, "Ndufs2, a Core Subunit of Mitochondrial Complex I, Is Essential for Acute Oxygen-Sensing and Hypoxic Pulmonary Vasoconstriction". Circ Res 125(8): e33-e34. doi: 10.1161/CIRCRESAHA.119.315815. 

 Wan J, Kalpage H, Vaishnav A, Liu J, Lee I, Mahapatra G, Moraes CT, Recanati M-A, Grossman LI, Salomon AR, Edwards BFP, Hüttemann M (2019). Cytochrome c Threonine 58 phosphorylation Regulates Respiration and Apoptosis. Scientific Reports, 9(1):15815. doi: 10.1038/s41598-019-52101-z. PMID: 31676852.

 Moreno-Domínguez A, Ortega-Sáenz P, Gao L, Colinas O, García-Flores P, Bonilla-Henao V, Aragonés J, Hüttemann M, Grossman LI, Weissmann N, Sommer N, López-Barneo J (2019). Acute oxygen sensing through HIF2a-dependent expression of atypical cytochrome oxidase subunits in arterial chemoreceptors. Science Signaling, 13(615). pii: eaay9452. doi: 10.1126/scisignal.aay9452. PMID: 31848220.

 Kalpage H, Vaishnav A, Liu J, Varughese A, Wan J, Ji Q, Kapralov AA, Kagan VE, Brunzelle JS, Recanati MA, Grossman LI, Sanderson TH, Lee I, Salomon RE, Edwards BFP, Hüttemann M (2019. Serine-47 Phosphorylation of Cytochrome c in the Mammalian Brain Regulates Mitochondrial Respiration and Apoptosis. FASEB J, 33(12):13503-13514. doi: 10.1096/fj.201901120R. PMID: 31570002.

 Erickson RP, Aras S , Hüttemann M, Dragotto J, Fiorenza MT, and Grossman LI (2019). Decreased membrane cholesterol in liver mitochondria of the point mutation mouse model of juvenile Niemann-Pick C1, Npc1nmf164. Mitochondrion, 51:15-21. doi: 10.1016/j.mito.2019.12.003. PMID: 31862414.

  Aras S, Maroun MC, Song Y, Bandyopadhyay S, Stark A, Yang Z, Grossman LI, and Fernández-Madrid F (2019). Mitochondrial autoimmunity and the role of MNRR1 in breast carcinogenesis. BMC Cancer. 19: 411. doi: 10.1186/s12885-019-5575-7.

 Talreja J, Talwar H, Bauerfeld C, Tranchida P, Grossman LI, and Samavati L (2019). HIF-1α Regulates IL-1β and IL-17 in Sarcoidosis. eLife, May 1;8. pii: e44519. doi: 10.7554/eLife.44519.

  Kalpage HA, Bazylianska V, Recanati MR, Fite A, Liu J, Wan J, Mantena N, Malek MH, Podgorski I , Heath EI, Vaishnav A, Edwards B, Grossman LI, Sanderson TH, Lee I, and Hüttemann M (2018). Tissue-Specific Regulation of Cytochrome c by Posttranslational Modifications: Respiration, the Mitochondrial Membrane Potential, ROS, and Apoptosis. FASEB J, 33: 1540-1553. PMID: 30222078

 Purandare N, Somayajulu M, Hüttemann M, Grossman LI, Aras S. (2018). CHCHD10 and MNRR1 (CHCHD2): Partners in mitochondrial and nuclear function and dysfunction. J Biol Chem, 293, 6517-6529.

 Sanderson TH, Wider JM, Lee I, Reynolds CA, Liu J, Lepore B, Tousignant R, Bukowski MJ, Johnston H, Fite A, Raghunayakula S, Kamholz J, Grossman LI, Przyklenk K, Hüttemann, M (2018). Inhibitory modulation of cytochrome c oxidase activity with specific near-infrared light wavelengths attenuates brain ischemia/reperfusion injury. Scientific Reports 8, 3481.