Siddhesh Aras works on oxidative phosphorylation, role of mitochondria in infectious diseases, transcriptional regulation of mitochondrial proteins.

Erin Carmany is a genetic counselor who works on genetic counseling in the Spanish speaking population, alternative genetic counseling service delivery models, patient written communication.

Molecular genetics of eye development and disease; cell-cell communication in nervous system maintenance and degeneration; glial support mechanisms; cell-specific transcriptional regulatory mechanisms

Gerald Feldman’s research is primarily directed towards clinical aspects of newborn screening and inborn errors of metabolism and the education of medical genetics and genomics residents and medical biochemical genetics fellows.

Functional genomics and systems biology;  Regulatory networks that control cell division in development and disease.

Methods research on survival analysis, generalized linear and multilevel models, high dimensional data, machine learning and Bayesian paradigm; design/analysis of clinical trials. Applications in health services, outcomes, and mental health research.

Dr. Gow focuses on generating (knockout, knockin, transgenic) and characterizing mouse models of developmental and adult-onset human CNS diseases: multiple sclerosis, leukodystrophies, cerebal palsy.

Adipose tissue cell and molecular biology and therapeutic tissue remodeling; single-cell functional genomics; lipolysis activation; co-evolution of lipid droplet binding proteins; novel therapeutic targets for metabolic disease and cancer.

Lawrence Grossman works on molecular genetics of the electron transport chain; cytochrome c oxidase; mitochondrial signaling and regulation; mitochondrial diseases.

Mitochondrial energy metabolism and apoptosis; regulation of cytochrome c and cytochrome c oxidase; cell signaling; noninvasive infrared light technology to treat ischemia-reperfusion injury; cancer

Gene Therapy; control of development and differentiation; expression of connective tissue genes and genes controlling spermatogenesis; computer-assisted sequence analysis.

Genomics Cancer Biology Genetics.

Regulation of smooth muscle cell dedifferentiation in response to genetic mutations and metabolic stresses during the pathogenesis of aortic aneurysms and atherosclerosis.

Functional and population genomics of intermediate phenotypes. Gene-environment interactions. Functional Genomics

Computational and statistical methods to study regulation of gene transcription, chromatin states, gene-environment interactions, and complex traits. Machine learning and integrative hierarchical Bayesian analysis of large genomic datasets.

Clinical and laboratory research in sarcoidosis and interstitial lung disease. Molecular Medicine.

Endoplasmic reticulum protein quality control and degradation, protein conformational diseases, physiology and metabolism.

Cancer genetic studies of familial cancers to determine the inherited cancer genes, analyze the mechanism of their action, and factors affecting genetic penetrance of the cancer phenotype. Bioinformatics.

Integrating genomics into primary care through provider education approaches; increasing access to genetic counseling; genetic counseling student admissions, education, and evaluation; genetic counselor career development.

Protein structure, function, classification and evolution; Disease-associated non-synonymous single-nucleotide polymorphism; Geometric matching, modeling, and molecular simulation. Computational Structural Biology.

Intracellular stress signaling from the endoplasmic reticulum and mitochondria; unfolded protein response and inflammation in metabolic diseases. Cell and Molecular Biology.

The lab studies the functions of ANGPTL8 (lipasin) and NADK2 (MNADK), two metabolism regulators that the lab identified, in mediating lipid metabolism and glucose homeostasis.

Cellular and molecular biology of monoamine neurotransmitter secreting neurons.

Papillomaviruses: molecular biology, evolution, and role in human carcinogenesis; cancer cell genome instability; ovarian carcinogenesis.

Studies the role of proteolipid protein in neonatal hypoxia ischemia and research of proteins in the myelin sheath that are critical for normal human function.

Mucosal Immunology, Reproductive immunology, Immunodeficiency, infection and inflammation, Cancer Immunology.

Rheumatoid Arthritis and Autoimmune Diseases.

Cell Culture, Cell Biology, Molecular Biology, Immunocytochemistry, Advanced Microscopy, Inner Ear Transplantation, and Functional Evaluation of Hearing.

Inherited Peripheral Nerve Diseases, Myelin Biology, Motor Neuron Diseases, Electromyography, Skin Biopsy for Evaluation of Peripheral Nerve Diseases.
Profile

Toxicogenomics of heavy metal exposure using Drosophila and human embryonic stem cell models.

Obesity and Diabetes, Nutrient-sensing hypothalamic circuits, Neurobiology of aging, Early postnatal environment.

Cellular and molecular physiology: Role for phosphoinositides in controlling membrane trafficking and peptide hormone signaling.

Diabetes, Cardiovascular disorders, Angiogenesis, Endothelium, Stress signaling.