Siddhesh Aras works on oxidative phosphorylation, role of mitochondria in infectious diseases, transcriptional regulation of mitochondrial proteins.

Erin Carmany is a genetic counselor who works on genetic counseling in the Spanish speaking population, alternative genetic counseling service delivery models, patient written communication.

Molecular genetics of eye development and disease; cell-cell communication in nervous system maintenance and degeneration; glial support mechanisms; cell-specific transcriptional regulatory mechanisms

Gerald Feldman’s research is primarily directed towards clinical aspects of newborn screening and inborn errors of metabolism and the education of medical genetics and genomics residents and medical biochemical genetics fellows.

Samiran Ghosh is a statistician whose methodological research focuses on survival analysis, generalized linear model, multilevel model, model selection in high dimensional data, machine learning and Bayesian paradigm. He is also interested in design and analysis of clinical trials. On the application side his major focus is on health services, outcomes research and mental health.

Dr. Gow focuses on generating (knockout, knockin, transgenic) and characterizing mouse models of developmental and adult-onset human CNS diseases: multiple sclerosis, leukodystrophies, cerebal palsy.

James Granneman works on adipose tissue cell and molecular biology; therapeutic adipose tissue remodeling; single cell functional genomics; molecular biology and biophysics of lipolysis activation; co-evolution of lipid droplet binding proteins; molecular pharmacology of ABHD5, a novel therapeutic target for metabolic disease and cancer.

Lawrence Grossman works on molecular genetics of the electron transport chain; cytochrome c oxidase; mitochondrial signaling and regulation; mitochondrial diseases..

Molecular cytogenetics; genome structure and function; genomic instability and cancer progression.

Mitochondrial energy metabolism and apoptosis; regulation of cytochrome c and cytochrome c oxidase; cell signaling; noninvasive infrared light technology to treat ischemia-reperfusion injury; cancer

Gene Therapy; control of development and differentiation; expression of connective tissue genes and genes controlling spermatogenesis; computer-assisted sequence analysis.

Genomics Cancer Biology Genetics.

Regulation of smooth muscle cell dedifferentiation in response to genetic mutations and metabolic stresses during the pathogenesis of aortic aneurysms and atherosclerosis.

Functional and population genomics of intermediate phenotypes. Gene-environment interactions. Functional Genomics

Computational methods and statistical genetic models to study regulation of gene transcription, chromatin state/accessibility, gene-environment interactions, and genetics of complex traits. Machine learning and integrative hierarchical Bayesian analysis of large genomic datasets (RNA-seq, ChIP-seq, DNA methylation, DNase-seq, ATAC-seq and also their single cell resolution variants) with genetic variation associated with molecular (eQTL) and complex traits (GWAS).

Clinical and laboratory research in sarcoidosis and interstitial lung disease. Molecular Medicine.

Endoplasmic reticulum protein quality control and degradation, protein conformational diseases, physiology and metabolism.

Cancer genetic studies of familial cancers to determine the inherited cancer genes, analyze the mechanism of their action, and factors affecting genetic penetrance of the cancer phenotype. Bioinformatics.

Developing and evaluating educational approaches for integrating genomics into primary care; evaluating ways to increase access to genetic counseling services; investigating genetic counseling outcomes;  genetic counseling student education, recruitment, and evaluation; genetic counselor career advancement.

Protein structure, function, classification and evolution; Disease-associated non-synonymous single-nucleotide polymorphism; Geometric matching techniques; Geometric modeling and molecular simulation. Computational Structural Biology.

Intracellular stress signaling from the endoplasmic reticulum and mitochondria; unfolded protein response and inflammation in metabolic diseases. Cell and Molecular Biology.

The lab studies the functions of ANGPTL8 (lipasin) and NADK2 (MNADK), two metabolism regulators that the lab identified, in mediating lipid metabolism and glucose homeostasis.

Cellular and molecular biology of monoamine neurotransmitter secreting neurons.

Papillomaviruses: molecular biology, evolution, and role in human carcinogenesis; cancer cell genome instability; ovarian carcinogenesis.

Mucosal Immunology, Reproductive immunology, Immunodeficiency, infection and inflammation, Cancer Immunology.

Rheumatoid Arthritis and Autoimmune Diseases.

Cell Culture, Cell Biology, Molecular Biology, Immunocytochemistry, Advanced Microscopy, Inner Ear Transplantation, and Functional Evaluation of Hearing.

Inherited Peripheral Nerve Diseases, Myelin Biology, Motor Neuron Diseases, Electromyography, Skin Biopsy for Evaluation of Peripheral Nerve Diseases.
Profile

Conducting translational, bench-to-bedside research focusing on the pathophysiology of acute coronary ischemic syndromes, the identification of cellular mechanisms and signaling pathways that increase the tolerance of the myocardium to ischemia, and the development of novel strategies to limit damage caused to the heart by ischemia-reperfusion.

Toxicogenomics of heavy metal exposure using Drosophila and human embryonic stem cell models.

Obesity and Diabetes, Nutrient-sensing hypothalamic circuits, Neurobiology of aging, Early postnatal environment.

Cellular and molecular physiology: Role for phosphoinositides in controlling membrane trafficking and peptide hormone signaling.

Studies the role of proteolipid protein in neonatal hypoxia ischemia and research of proteins in the myelin sheath that are critical for normal human function.

Diabetes, Cardiovascular disorders, Angiogenesis, Endothelium, Stress signaling.