Lobelia Samavati, MD

Lobelia Samavati, MD
Professor of Molecular Medicine and Genetics and of Internal Medicine
Director, Sarcoidosis/ILD Center
Scott Hall, Rm 3228
540 E. Canfield Avenue
Detroit, MI 48201


Regulation of the lung innate and adaptive immune responses

Technology development to identify disease specific immunoglobulins

Mouse Model Clinical Research


Medical School at the University of Cologne, MD, 1992

Research Focus

Clinical and laboratory research in sarcoidosis and interstitial lung disease.

Our research group interests are focused on discovery of mechanisms related to human diseases in response to microbial and environmental stressors. We apply state of the art tools including, molecular and cell biology, metabolomics, and genetics to dissect the molecular mechanisms and to identify the determinant factor(s) related to human phenotypic diversity and clinical manifestation of diseases.

Recent Publications

Talwar H, Hanoudi SN, Draghici S, Samavati L. Novel T7 Phage Display Library
Detects Classifiers for Active Mycobacterium Tuberculosis Infection. Viruses.
2018 Jul 19;10(7). pii: E375. doi: 10.3390/v10070375. PubMed PMID: 30029479.

Talreja J, Samavati L. K63-Linked Polyubiquitination on TRAF6 Regulates
LPS-Mediated MAPK Activation, Cytokine Production, and Bacterial Clearance in
Toll-Like Receptor 7/8 Primed Murine Macrophages. Front Immunol. 2018 Feb
21;9:279. doi: 10.3389/fimmu.2018.00279. eCollection 2018. PubMed PMID: 29515583;
PubMed Central PMCID: PMC5826352.

Talwar H, Hanoudi SN, Geamanu A, Kissner D, Draghici S, Samavati L. Detection 
of Cystic Fibrosis Serological Biomarkers Using a T7 Phage Display Library. Sci
Rep. 2017 Dec 18;7(1):17745. doi: 10.1038/s41598-017-18041-2. PubMed PMID:
29255267; PubMed Central PMCID: PMC5735098.

Bauerfeld C, Samavati L. Role of MEK1 in TLR4 Mediated Signaling. J Cell
Signal. 2017 Mar;2(1). pii: 135. Epub 2017 Feb 13. PubMed PMID: 28804793; PubMed 
Central PMCID: PMC5553978.

Talwar H, Bauerfeld C, Liu Y, Samavati L. The dataset describes: HIF-1 α
expression and LPS mediated cytokine production in MKP-1 deficient bone marrow
derived murine macrophages. Data Brief. 2017 Jul 20;14:56-61. doi:
10.1016/j.dib.2017.07.036. eCollection 2017 Oct. PubMed PMID: 28765831; PubMed
Central PMCID: PMC5526519.

Talreja J, Farshi P, Alazizi A, Luca F, Pique-Regi R, Samavati L.
RNA-sequencing Identifies Novel Pathways in Sarcoidosis Monocytes. Sci Rep. 2017 
Jun 2;7(1):2720. doi: 10.1038/s41598-017-02941-4. PubMed PMID: 28577019; PubMed
Central PMCID: PMC5457404.

Talwar H, Bauerfeld C, Bouhamdan M, Farshi P, Liu Y, Samavati L. MKP-1
negatively regulates LPS-mediated IL-1β production through p38 activation and
HIF-1α expression. Cell Signal. 2017 Jun;34:1-10. doi:
10.1016/j.cellsig.2017.02.018. Epub 2017 Feb 24. PubMed PMID: 28238855; PubMed
Central PMCID: PMC5410178.

Talwar H, Talreja J, Samavati L. T7 Phage Display Library a Promising Strategy
to Detect Tuberculosis Specific Biomarkers. Mycobact Dis. 2016 Jun;6(2). pii:
214. Epub 2016 Jun 28. PubMed PMID: 27867751; PubMed Central PMCID: PMC5111870.

Kingah P, Alam M, Chugh K, Kamholz J, Samavati L. Role of Pulmonary Evaluation
in Diagnosis of Neurosarcoidosis. Sarcoidosis Vasc Diffuse Lung Dis. 2016 Oct
7;33(3):209-215. PubMed PMID: 27758985.

Geamanu A, Gupta SV, Bauerfeld C, Samavati L. Metabolomics connects aberrant 
bioenergetic, transmethylation, and gut microbiota in sarcoidosis. Metabolomics. 
2016 Feb;12. pii: 35. Epub 2016 Jan 20. PubMed PMID: 27489531; PubMed Central
PMCID: PMC4960975.

Complete publications list.