Stephen A. Krawetz, PhD

Stephen A. Krawetz, PhD
Professor of Obstetrics and Gynecology and of Molecular Medicine and Genetics
Charlotte B. Failing Professor of Fetal Therapy and Diagnosis
Associate Director, C.S. Mott Center for Human Grown and Development
C.S. Mott, Rm 253
275 E. Hancock
Detroit, MI 48201
313-577-6770
steve@compbio.med.wayne.edu

Education

University of Toronto, PhD, 1983

Research Focus

His group has published over 200 manuscripts detailing the regulation of gene expression by chromatin structure emphasizing human spermatogenesis and its application to personalized medicine.  The interaction of genome structure and function continues to be highlighted throughout his research program. Over the last two decades, his group established that the fitness of the paternal contribution reflects the relative diversity of sperm RNAs that continually responds to the environment.  They showed that at fertilization the spermatozoon delivers a cadre of unique RNAs to the oocyte.  These RNAs may provide an essential component to early paternal genome reprogramming acting as genetic and epigenetic impactors of the fetal onset of adult disease.  They provide a personalized timestamp of the physical and reproductive health of Dad, providing the opportunity to develop a personalized blueprint promoting the birth and healthy life of his children.

Recent Publications

Steiner, A.Z., Hansen, K.R., Barnhart, K.T., Cedars, M.I., Legro, R.S., Diamond, M.P., Krawetz, S.A., Usadi, R., Baker, V.L., Coward, R.M., Huang, H.1., Wild, R., Masson, P., Smith, J.F., Santoro. N., Eisenberg, E., Zhang, H.; Reproductive Medicine Network.  (online 2020) The effect of antioxidants on male factor infertility: the Males, Antioxidants, and Infertility (MOXI) randomized clinical trial.  Fertility and Sterility. PMID: 32111479.

Swanson, G.M., Moskovtsev, S., Librach, C., Pilsner, J.R. Ph., Goodrich, R. and Krawetz, S.A. (2020) What human sperm RNA-Seq tells us about the microbiome.  Journal of Assisted Reproduction and Genetics 37:359-368.  PMID: 31902104.

Wang, Z., Shi, Y.,  Suhengm M.,  Qian M.,  Huang, Q., Yap, Y., Shi, L., Zhang, S., Zhou, T., Li, W., Hu, B., Zhang L., Krawetz, S.A., Pazour, G., Rex Hess, R., and Zhang, Z, (2020) Abnormal fertility, acrosome formation, IFT20 expression and localization in the conditional Gmap210 knockout mice.  American Journal of Physiology-Cell Physiology 318:174-190. PMID: 31577511.

Estill, M., Hauser, R., Moss, A.E., Nassan F. and Krawetz, S.A. (2019) The effects of di-butyl phthalate exposure from medications on human sperm RNA among men. Nature Scientific Reports.  9:12397 PMID: 31455814.

Swanson, G., Estill, M., Diamond, M.P., Legro, R.S., Coutifaris, C., Barnhart, M.D., Huang, H., Hansen, K.R., Trussell, M.D., Coward, R.M. Zhang, H., Goodrich, R. and Krawetz, S.A. (2020) Human Chromatin remodeler cofactor, RNA interactor, Eraser and Writer Sperm RNAs responding to Obesity. Epigenetics. 15:32-46. PMID: 31354029.

Estill, M.S., Hauser, R. Krawetz, S.A. (2019) RNA element discovery from germ cell to blastocyst.

Nucleic Acids Research 47:2263–2275. (cover feature) PMID: 30576549

Archana, S.S., Selvaraju,S.,  Binsila, B.K., Arangasamy, A., Krawetz, S.A. Immune regulatory molecules as modifiers of semen and fertility: A Review. (2019) Molecular Reproduction and Development. 86:1485-1504. PMID: 31518041

National Academies of Sciences, Engineering and Medicine Gulf War and Health: Volume 11: Generational Health Effects of Serving in the Gulf War (2018) PMID: 30629394.