Stephen A. Krawetz, PhD

Education

University of Toronto, PhD, 1983

Research Focus

His group has published over 200 manuscripts detailing the regulation of gene expression by chromatin structure emphasizing human spermatogenesis and its application to personalized medicine.  The interaction of genome structure and function continues to be highlighted throughout his research program. Over the last two decades, his group established that the fitness of the paternal contribution reflects the relative diversity of sperm RNAs that continually responds to the environment.  They showed that at fertilization the spermatozoon delivers a cadre of unique RNAs to the oocyte.  These RNAs may provide an essential component to early paternal genome reprogramming acting as genetic and epigenetic impactors of the fetal onset of adult disease.  They provide a personalized timestamp of the physical and reproductive health of Dad, providing the opportunity to develop a personalized blueprint promoting the birth and healthy life of his children.

Mentoring

Accepting new M.S. students in 2024/2025

Accepting new Ph.D. students in 2024/2025

Recent Publications

Hamilton, M., Russell, S.,  Swanson, G.M.,  Krawetz, S.A., Menezes, K., Moskovtsev, S.I., Librach, C. (2024) A comprehensive analysis of spermatozoal RNA elements in idiopathic infertile males undergoing fertility treatment.  Nature Scientific Reports, 14:10316 | doi.org/10.1038/s41598-024-60586-6.  PMID: 38705876 

Ntostis, P., Swanson, G., Kokkali, G., Iles, D., Huntriss, J., Pantou, A., Tzetis, M., Pantos, K., Picton, H.M., Krawetz, S.A., and Miller, D. (2021) The effects of aging on molecular modulators of human embryo implantation iScience.  19;24(7):102751. doi: 10.1016/j.isci.2021.102751. PMID: 34278260 

Estill, M., Hauser, R., Moss, A.E., Nassan F. and Krawetz, S.A. (2019) The effects of di-butyl phthalate exposure from medications on human sperm RNA among men.  Nature Scientific Reports.  9:12397 PMID: 31455814.  

Estill, M.S., Hauser, R. Krawetz, S.A. (2019) RNA element discovery from germ cell to blastocyst.  Nucleic Acids Research 47:2263–2275.  (cover feature) PMID: 30576549 

Burl, R.B., Clough, S., Sendler, E., Estill, M and Krawetz, S.A. (2018) Sperm RNA elements as markers of health.  Systems Biology in Reproductive Medicine.  64:25-38. PMID: 29199464 

National Academies of Sciences, Engineering, and Medicine; Health and Medicine Division; Board on Population Health and Public Health Practice; Committee on Gulf War and Health, Volume 11: Generational Health Effects of Serving in the Gulf War.  (2018) ISBN 978-0-309-47823-6 PMID: 30629394.