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Graduate Programs in Molecular Genetics and Genomics

Challenging, research intensive PhD and MS graduate programs which prepare students for careers in academia and industry.

Genetics Residencies & Fellowships

Provide medical care to patients with birth defects, metabolic diseases, and a family history of inherited conditions.

MASTERS DEGREE IN GENETIC COUNSELING

Develop the skills and knowledge to become a professional genetic counselor.

AGRADE PROGRAM

Get a jump on graduate study with this novel Accelerated Graduate Enrollment program.

News

Erin Carmany, MS, CGC (Associate Professor of Molecular Medicine and Genetics and Associate Director of the Genetic Counseling Graduate Program) was selected to receive one of the 2024 President’s Awards for Excellence in Teaching in recognition of her contributions to the academic excellence of Wayne State University students. Professor Carmany is a gifted, caring, and enthusiastic teacher and mentor who engages her students and promotes their success.

Maik Hüttemann, PhD (Professor of Molecular Medicine and Genetics and of Biochemistry, Microbiology and Immunology) was recently awarded the Wayne State University Board of Governors Faculty Recognition Award for the publication of “Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle” (Nature Communications). This publication reveals that cytochrome c undergoes acetylation during ischemia, indicating reduced oxygen supply. This discovery represents an important advancement in the field of biology, with potentially far-reaching implications for human health and medicine.

CMMG Faculty recently awarded grant from National Multiple Sclerosis Society to study metabolic stress and oligodendrocyte pathophysiology. Alexander Gow, PhD, Professor and Associate Director of the Center for Molecular Medicine and Genetics and Professor of Pediatrics and Neurology was recently awarded a three-year grant from the National Multiple Sclerosis Society to study metabolic stress and oligodendrocyte pathophysiology. Professor Gow and colleagues have identified a protein in cells that makes nerve-insulating myelin, called oligodendrocytes. The protein (Trb3) appears to drastically reduce metabolic stress and its negative impact on health in mice. In this project, they are testing this protein and other proteins that Trb3 seems to interact with, by “deleting” them in mouse models. They are studying these models to see how each protein affects metabolic stress and how the process of myelin formation is affected.

Wayne State University awarded $1.4 million from Department of Defense to expand on research findings surrounding prostate cancer
A team of researchers from Wayne State University was awarded a $1.4 million, three-year grant from the U.S. Department of Defense for the study, “Cytochrome c acetylation drives prostate cancer aggressiveness and Warburg effect.”
The study, led by Maik Hüttemann, PhD, Professor of Molecular Medicine and Genetics, and biochemistry, microbiology and immunology at Wayne State University’s School of Medicine, aims to establish the role of the protein cytochrome c, which the team proposes is central in two hallmarks of cancer: switching from aerobic to glycolytic metabolism – also known as the Warburg effect – and evasion of apoptosis.

John Kamholz, MD, PhD, formerly Professor of Neurology and of Molecular Medicine and Genetics at Wayne State University, died on February 2, 2024. He was a valued and stimulating colleague. We extend our deepest sympathies and condolences to John's family and loved ones during this difficult time

 

Dr. Lobelia Samavati, MD, Professor of Internal Medicine and of Molecular Medicine and Genetics, recently showed that a cytokine called MIF modulates cytokine networks in the disease sarcoidosis, More detail is found in her report, "MIF modulates p38/ERK phosphorylation via MKP-1 induction in sarcoidosis", published in iScience.

Dr. Adi Tarca, PhD, Professsor of Molecular Medicine and Genetics and of Obstetrics & Gynecology, recently selected to join the DREAM board as a Director of DREAM challenges. The DREAM "Challenges is a community-driven organization whose mission is to promote open, reproducible and collaborative scientific research in biomedicine. DREAM today is recognized as a leader in biomedical challenges, with a proven methodology for motivating research teams to solve complex and ground-breaking problems in biology and biomedicine."

Dr. James Granneman, PhD, Professor of Molecular Medicine and Genetics and of Internal Medicine, will lead the new Barber Integrative Metabolic Research Program. Alongside a multidisciplinary team of researchers, Dr. Granneman will be investigating the "understanding the intricacies of cellular lipid metabolism" in an effort to understand the progression of many metabolic diseases. Read more about this new initiative here!

Upcoming Events

For more information email Suzanne Shaw 

Jun
13

11:00 a.m., 3140 Scott Hall

SURP Seminar

Calendar of Events

 

CMMG Spotlight:

Newsletter articles highlighting CMMG faculty, students, and events. Click here to read other articles from the CMMG newsletter.

Simple blood test can quickly diagnose sarcoidosis

hand holding an illustrative glowing lungThis test was designed by Lobelia Samavati, MD, Professor of Internal Medicine and of Molecular Medicine and Genetics. She said, "More testing needs to be completed before this screening method is ready for clinical use, but it’s possible that could be a reality within a few years,” The test was announced by NHLBI, the NIH institute that has funded the work.

CREBH-C, a new hepatokine that helps control triglyceride levels 

Featuring the recent work of Dr. Kezhong Zhang, PhD, Professor of Molecular Medicine and Genetics and of Biochemistry, Microbiology, and Immunology, regarding the gene CREBH-C and its implications.

Focus on CMMG graduate students: Paul Morse

Featuring former MD-PhD student: Paul Morse, PhD, who worked with Dr. Maik Hüttemann, PhD, Professor of Molecular Medicine and Genetics and of Biochemistry, Microbiology, and Immunology.

Ischemia Reperfusion Injury: from the lab to the clinic

Featuring the work of Dr. Maik Hüttemann, PhD, Professor of Molecular Medicine and Genetics and of Biochemistry, Microbiology, and Immunology, who was recently awarded a NIH U44 grant for this work.

Racial disparities in cancer genetic counseling being examined 

Featuring Erin Carmany, MS, CGC, Associate Professor of Molecular Medicine and Genetics and Associate Director, Genetic Counseling Masters Program. Read the published study here!

New collaboration to evaluate large-scale proteomics data for prediction of preeclampsia

Dr. Adi Tarca, PhD, Professor of Molecular Medicine and Genetics and of Obstetrics & Gynecology, has established a collaboration with Dr. Trond Michelson, University of Oslo (Norway), to conduct a cross-cohort evaluation of large-scale proteomics data for the prediction of preeclampsia. A postdoctoral researcher from Dr. Michelson's lab will join Dr. Tarca's lab at CMMG for 6 months to work on this collaborative project.

Recent research 

MIF modulates p38/ERK phosphorylation via MKP-1 induction in sarcoidosis. Talreja, J; Peng, C; Samavati, Lobelia. iScience. 2024 Jan 19; doi: 10.1016/j.isci.2023.108746.

Mitochondrial Oxidative Phosphorylation in Viral Infections.  Purandare N, Ghosalkar E, Grossman LI, Aras S.  Viruses. 2023 Dec 4;15(12):2380. doi: 10.3390/v15122380. PMID: 38140621; PMCID: PMC10747082.

Modulation of mitochondrial function with near-infrared light reduces brain injury in a translational model of cardiac arrest. Wider JM, Gruley E, Morse PT, Wan J, Lee I, Anzell AR, Fogo GM, Mathieu J, Hish G, O'Neil B, Neumar RW, Przyklenk K, Hüttemann M, Sanderson TH. Crit Care. 2023 Dec 14;27(1):491. doi: 10.1186/s13054-023-04745-7. PMID: 38098060; PMCID: PMC10720207.

DNA damage-induced lncRNA MEG9 impacts angiogenesis. Eugenia Fraile-Bethencourt, Sokchea Khou, RaeAnna Wilson, Adrian Baris, Rebecca Ruhl, Cristina Espinosa-Diez, Sudarshan Anand bioRxiv 2022.12.07.519382; doi: https://doi.org/10.1101/2022.12.07.519382

Racial disparities in cancer genetic counseling encounters: study protocol for investigating patient-genetic counselor communication in the naturalistic clinical setting using a convergent mixed methods design.Hagiwara N, Harika N, Carmany EP, Shin Y, Eggly S, Jones SCT, Quillin J. BMC Cancer. 2023 Oct 16;23(1):983. doi: 10.1186/s12885-023-11486-x. PMID: 37845629; PMCID: PMC10578042.

Insights into elastic fiber fragmentation: Mechanisms and treatment of aortic aneurysm in Marfan syndrome.Seeburun S, Wu S, Hemani D, Pham L, Ju D, Xie Y, Kata P, Li L. Vascul Pharmacol. 2023 Aug 26;153:107215. doi: 10.1016/j.vph.2023.107215. Epub ahead of print. PMID: 37640090.

Contemporary Antiretroviral Therapy Dysregulates Iron Transport and Augments Mitochondrial Dysfunction in HIV-Infected Human Microglia and Neural-Lineage Cells. Kaur H, Minchella P, Alvarez-Carbonell D, Purandare N, Nagampalli VK, Blankenberg D, Hulgan T, Gerschenson M, Karn J, Aras S, Kallianpur AR.  Int J Mol Sci. 2023 Jul 31;24(15):12242. doi: 10.3390/ijms241512242. PMID: 37569616; PMCID: PMC10419149

The MNRR1 activator nitazoxanide abrogates lipopolysaccharide-induced preterm birth in mice. Purandare N, Gomez-Lopez N, Arenas-Hernandez M, Galaz J, Romero R, Xi Y, Fribley AM, Grossman LI, Aras S. Placenta. 2023 Jul 8;140:66-71. doi: 10.1016/j.placenta.2023.07.005. Epub ahead of print. PMID: 37544161.

Genetic control of the dynamic transcriptional response to immune stimuli and glucocorticoids at single-cell resolution. Resztak JA, Wei J, Zilioli S, Sendler E, Alazizi A, Mair-Meijers HE, Wu P, Wen X, Slatcher RB, Zhou X, Luca F, Pique-Regi R. Genome Res. 2023 Jun; 33(6):839-856. doi: 10.1101/gr.276765.122.

Cytochrome c lysine acetylation regulates cellular respiration and cell death in ischemic skeletal muscle.Morse PT, Pérez-Mejías G, Wan J, Turner AA, Márquez I, Kalpage HA, Vaishnav A, Zurek MP, Huettemann PP, Kim K, Arroum T, De la Rosa MA, Chowdhury DD, Lee I, Brunzelle JS, Sanderson TH, Malek MH, Meierhofer D, Edwards BFP, Díaz-Moreno I, Hüttemann M. Nat Commun. 2023 Jul 13;14(1):4166. doi: 10.1038/s41467-023-39820-8.

The New Year of Systems Biology in Reproductive Medicine. Krawetz SA. 2023. Sys Biol Reprod Med.13:1-2. doi: 10.1080/19396368.2023.2156032. 

Hepatic SEL1L-HRD1 ER-associated degradation regulates systemic iron homeostasis via ceruloplasmin. Thepsuwan P, Bhattacharya A, Song Z, Hippleheuser S, Feng S, Wei X, Das NK, Sierra M, Wei J, Fang D, Huang YM, Zhang K, Shah YM, Sun S. 2023. Proc Natl Acad Sci USA. doi:10.1073/pnas.2212644120