Cristina Espinosa-Diez, PhD

Cristina Espinosa-Diez, PhD (She/her/ella)

Assistant Professor of Molecular Medicine and Genetics and of Physiology
Scott Hall, 3240
540 E. Canfield Street
Detroit, MI 48201
email here ...

Education and Training

University Complutense, Madrid, Spain PhD, 2015

Postdoctoral researcher, Oregon Health and Science University, 2015

Postdoctoral fellow, University of Pittsburgh, 2019

Research Interests

We are a non-coding-RNA lab interested in understanding how cancer therapies shape the epigenetic landscape of vascular cells, potentially giving rise to long-term vascular complications. The lab's main goals are :

  1. To explore the response of long-non-coding RNAs to different anti-cancer agents.
  2. To investigate these long-non-coding RNAs' role in vascular remodeling during disease progression.

Research Focus

Molecular Biology, Epigenetics, vascular biology, non-coding-RNAs.


Accepting new Ph.D. students in 2023/2024

Not accepting new M.S. students in 2023/2024


Highlighted manuscripts

DNA damage-induced lncRNA MEG9 impacts angiogenesis. Eugenia Fraile-Bethencourt, Sokchea Khou, Rebecca Ruhl, Adrian Baris, Cristina Espinosa-Diez*, Sudarshan Anand*. BioRxiv 519382; doi: (Under revision in iScience) *Corresponding authors.

miRNA/mRNA co-profiling identifies the miR-200 family as a central regulator of SMC quiescence. Mingyuan Du, Cristina Espinosa-Diez, Mingjun Liu, Sidney Mahan, Delphine Gomez. iScience. (May 2022). PMID: 35465051

H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity. Mingjun Liu, Cristina Espinosa-Diez, Sidney Mahan, Mingyuan Du, Anh T. Nguyen, Scott Hahn, Raja Chakraborty, Adam C. Straub, Kathleen A. Martin, Gary K. Owens, Delphine Gomez. Developmental cell. (October 2021). PMID: 34582749

Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via downregulation of acid sphingomyelinase. Shushan Rana, Cristina Espinosa-Diez, Rebecca Ruhl, Namita Chatterjee, Clayton Hudson, Eugenia Fraile-Bethencourt, Anupriya Agarwal, Sokchea Khou, Charles R. Thomas, Sudarshan Anand. Scientific Reports (March 2020). PMID: 32221387

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence and angiogenic signaling. Cristina Espinosa-Diez, RaeAnna Wilson, Namita Chatterjee, Clayton Hudson, Rebecca Ruhl, Christina Hipfinger, Erin Helms, Omar F Khan, Daniel G Anderson, Sudarshan Anand. Cell Death and Disease (June 2018). PMID: 29795397

MicroRNA regulation of endothelial TREX1 reprograms the tumor microenvironment. RaeAnna Wilson*, Cristina Espinosa-Diez*, Nathan Kanner, Namita Chaterjee, Rebeca Ruhl, Christina Hipfinger, Sunil J. Advani, Jie Li, Omar F. Khan, Aleksandra Franovic, Sara M. Weis, Daniel G. Anderson, Clark C Chen, Sushil Kumar, Lisa M. Coussens, David A. Cheresh and Sudarshan Anand. Nature Communications (December 2016). *Equal contribution. PMID: 27886180

Specific Endothelial deletion of GCLc in mice cause a redox depend vascular dysfunction. Cristina Espinosa-Diez*, Verónica Miguel*, Susana Vallejo, Elena Sandoval-Pinto, Francisco Sánchez-Gómez, Eva M Blanco, Concepción Peiro, Carlos Sanchez-Ferrer and Santiago Lamas. Redox Biology (September 2017) *Equal contribution. PMID: 28888203

Targeting of gamma-glutamyl-cysteine ligase by miR-433 reduces glutathione biosynthesis and promotes TGF-β-dependent fibrogenesis. Cristina Espinosa-Diez, Marta Fierro-Fernández, Francisco Sánchez-Gómez, Fernando Rodríguez-Pascual, Matilde Alique, Marta Ruiz-Ortega, Naiara Beraza, Maria L Martinez Chantar, Carlos Fernández-Hernando and Santiago Lamas. Antioxidant and Redox signaling (November 2014). PMID: 25353619

Full list of publications:

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