Education and Training

University Complutense, Madrid, Spain PhD, 2015

Postdoctoral researcher, Oregon Health and Science University, 2015

Postdoctoral fellow, University of Pittsburgh, 2019

Research Interests

We are a non-coding-RNA lab interested in understanding how cancer therapies shape the epigenetic landscape of vascular cells, potentially giving rise to long-term vascular complications. The lab's main goals are :

1. To explore the response of long-non-coding RNAs to different anti-cancer agents.
2. To investigate these long-non-coding RNAs' role in vascular remodeling during disease progression.

Research Focus

Molecular Biology, Epigenetics, vascular biology, non-coding-RNAs.

Mentoring

Accepting new Ph.D. students in 2023/2024

Not accepting new M.S. students in 2023/2024

Publications

Highlighted manuscripts

DNA damage-induced lncRNA MEG9 impacts angiogenesis. Eugenia Fraile-Bethencourt, Sokchea Khou, Rebecca Ruhl, Adrian Baris, Cristina Espinosa-Diez*, Sudarshan Anand*. BioRxiv 519382; doi: https://doi.org/10.1101/2022.12.07.519382. (Under revision in iScience) *Corresponding authors.

miRNA/mRNA co-profiling identifies the miR-200 family as a central regulator of SMC quiescence. Mingyuan Du, Cristina Espinosa-Diez, Mingjun Liu, Sidney Mahan, Delphine Gomez. iScience. (May 2022). PMID: 35465051

H3K4 di-methylation governs smooth muscle lineage identity and promotes vascular homeostasis by restraining plasticity. Mingjun Liu, Cristina Espinosa-Diez, Sidney Mahan, Mingyuan Du, Anh T. Nguyen, Scott Hahn, Raja Chakraborty, Adam C. Straub, Kathleen A. Martin, Gary K. Owens, Delphine Gomez. Developmental cell. (October 2021). PMID: 34582749

Differential regulation of microRNA-15a by radiation affects angiogenesis and tumor growth via downregulation of acid sphingomyelinase. Shushan Rana, Cristina Espinosa-Diez, Rebecca Ruhl, Namita Chatterjee, Clayton Hudson, Eugenia Fraile-Bethencourt, Anupriya Agarwal, Sokchea Khou, Charles R. Thomas, Sudarshan Anand. Scientific Reports (March 2020). PMID: 32221387

MicroRNA regulation of the MRN complex impacts DNA damage, cellular senescence and angiogenic signaling. Cristina Espinosa-Diez, RaeAnna Wilson, Namita Chatterjee, Clayton Hudson, Rebecca Ruhl, Christina Hipfinger, Erin Helms, Omar F Khan, Daniel G Anderson, Sudarshan Anand. Cell Death and Disease (June 2018). PMID: 29795397

MicroRNA regulation of endothelial TREX1 reprograms the tumor microenvironment. RaeAnna Wilson*, Cristina Espinosa-Diez*, Nathan Kanner, Namita Chaterjee, Rebeca Ruhl, Christina Hipfinger, Sunil J. Advani, Jie Li, Omar F. Khan, Aleksandra Franovic, Sara M. Weis, Daniel G. Anderson, Clark C Chen, Sushil Kumar, Lisa M. Coussens, David A. Cheresh and Sudarshan Anand. Nature Communications (December 2016). *Equal contribution. PMID: 27886180

Specific Endothelial deletion of GCLc in mice cause a redox depend vascular dysfunction. Cristina Espinosa-Diez*, Verónica Miguel*, Susana Vallejo, Elena Sandoval-Pinto, Francisco Sánchez-Gómez, Eva M Blanco, Concepción Peiro, Carlos Sanchez-Ferrer and Santiago Lamas. Redox Biology (September 2017) *Equal contribution. PMID: 28888203

Targeting of gamma-glutamyl-cysteine ligase by miR-433 reduces glutathione biosynthesis and promotes TGF-β-dependent fibrogenesis. Cristina Espinosa-Diez, Marta Fierro-Fernández, Francisco Sánchez-Gómez, Fernando Rodríguez-Pascual, Matilde Alique, Marta Ruiz-Ortega, Naiara Beraza, Maria L Martinez Chantar, Carlos Fernández-Hernando and Santiago Lamas. Antioxidant and Redox signaling (November 2014). PMID: 25353619

Full list of publications:
https://www.ncbi.nlm.nih.gov/myncbi/maria%20cristina.espinosa-diez.1/bib...

Google scholar:
https://scholar.google.com/citations?user=HUy4tqAAAAAJ&hl=en