Lawrence I. Grossman, PhD
Director, Center for Molecular Medicine and Genetics
Professor of Internal Medicine
Scott Hall, Rm 3129
540 E. Canfield Avenue
Detroit, MI 48201
Albert Einstein College of Medicine, PhD, 1971
We work on mitochondrial molecular genetics. Mitochondria are semi-autonomous organelles because they have their own DNA and genetic machinery but must cooperate with the nucleus to function. Mitochondria contain about 1500 proteins, most nucleus encoded, and carry out a number of functions, most centrally to provide most of the energy in the cell. So important is proper energy functionin that mitochondria turn out to be responsible for, or to be involved in, a growing array of diseases, including many common late onset diseases such as various peripheral neuropathies, cardiomyopathies, and type II diabetes. We are focusing increasingly on mitochondrial disease mechanisms, including genomic approaches to population disease susceptibilities. We are also interested in the evolutionary emergence of an enlarged neocortex, the most highly oxygen-utilizing tissue.
Aras S, Arrabi H, Punandare N, Hüttemann M, Kamholz J, Züchner S, Grossman LI (2017). Abl2 phosphorylates MNRR1 in mitochondria, activating respiration, and is deficient in a Charcot-Marie-Tooth disease associated mutant, giving an exaggerated presentation. Biochim Biophys Acta, 1864: 440-448. PMID: 27913209
Mahapatra G, Varughese A, Ji Q, Lee I, Liu J, Vaishnav A, Sinkler C, Kapralov AA, Moraes CT, Sanderson TH, Stemmler TL, Grossman LI, Kagan VE, Brunzelle JS, Salomon AR, Edwards BFP, Hüttemann M (2017). Phosphorylation of cytochrome c threonine 28 regulates electron transport chain activity in kidney. J Biol Chem 292:64-79.
Zhang K, Wang G, Zhang X, Hüttemann PP, Qiu Y, Liu J, Mitchell A, Lee I, Zhang C, Lee J, Pecina P, Wu G, Yang Z, Hüttemann Maik, Grossman LI (2016). COX7AR is a stress-inducible mitochondrial COX subunit that promotes breast cancer malignancy. Sci Reports 6:31742. PMID: 27550821
Aras S, Bai M, Lee I, Springett R, Hüttemann M, Grossman LI (2015). MNRR1 (formerly CHCHD2) is a bi-organellar regulator of mitochondrial metabolism. Mitochondrion 20, 43-51. PMID: 25315652
Fernández Madrid F, Maroun M-C, Olivero O, Long M, Stark A, Grossman LI, Binder W, Dong J, Burke M, Nathanson SD, Zarbo R, Chitale D, Zeballos-Chávez R, Peebles C (2015). Autoantibodies in breast cancer sera are not epiphenomena and may participate in carcinogenesis. BMC Cancer 15: 407. PMID: 25975273
Lipovich L, Hou ZC, Jia H, Sinkler C, McGowen M, Sterner KN, Weckle A, Sugalski AB, Pipes L, Gatti D, Mason CE, Sherwood CC, Hof PR, Kuzawa CW, Grossman LI, Goodman M, Wildman DE (2015). High-throughput RNA sequencing reveals structural differences of orthologous brain-expressed genes between western lowland gorillas and humans. J Comp Neurol 524(2):288-308. PMID: 26132897
Horsch M, Aguilar-Pimente JA, Bönisch C, Côme C, Kolster-Fog C, Jensen KT, Lund AH, Lee I, Grossman LI, Sinkler C, Hüttemann M, Bohn E, Fuchs H, Ollert M, Gailus-Durner V, Hrabê de Angelis M, Beckers J, (2015) Cox4i2, Ifit2, and Prdm11 Mutant Mice: Effective Selection of Genes Predisposing to an Altered Airway Inflammatory Response from a Large Compendium of Mutant Mouse Lines. PLoS One, 10(8):e0134503.
Maurer SF, Fromme T, Grossman LI, Hüttemann M and Martin Klingenspor (2015). The brown and brite adipocyte marker Cox7a1 is not required for non-shivering thermogenesis in mice. Sci Reports 5: 17704.
Pierron D, Razafindrazaka H, Rocher C, Letellier T, Grossman LI (2014). Human testis specific genes are under relaxed negative selection. Molec Genet Genomics 289, 37-45. PMID: 24202551
Hüttemann M, Doan JW, Goustin AS, Sinkler C, Mahapatra G, Shay J, Liu J, Elbaz H, Aras S, Grossman LI, Ding Y, Zielske SP, Malek MH, Sanderson TH, Lee I (2014). Regulation of cytochrome c in respiration, apoptosis, neurodegeneration and cancer – the good, the bad and the ugly. In Cytochrome C: Electrochemistry, Biological Functions and Pathophysiological Implications. Hauppauge, NY: Nova Science Publishers. ISBN: 978-1-63117-467-4
Duka T, Anderson SM, Collins Z, Raghanti MA, Ely JJ, Hof PR, Wildman DE, Goodman M, Grossman LI, Sherwood CC (2014). Synaptosomal Lactate Dehydrogenase Isoenzyme Composition Is Shifted toward Aerobic Forms in Primate Brain Evolution. Brain Behav Evol 83, 216-230. PMID: 24686273
Kuzawa CW, Chugani HT, Grossman LI, Lipovich L, Muzik O, Hof PR, Wildman DE, Sherwood CC, Leonard WR, Lange N (2014). Metabolic costs and evolutionary implications of human brain development. Proc Natl Acad Sci USA 111, 13010-13015. PMID: 25157149
Kuzawa CW, Chugani HT, Grossman LI, Lipovich L, Muzik O, Hof PR, Wildman DE, Sherwood CC, Leonard WR, Lange N (2014). Reply to Skoyles: Decline in growth rate, not muscle mass, predicts the human childhood peak in brain metabolism. Proc Natl Acad Sci USA 111, E4910. PMID: 25385651