Alexander Gow, PhD

Alexander Gow, PhD
Professor of Molecular Medicine and Genetics and of Pediatrics and of Neurology
Charles H. Gershenson Distinguished Fellow
Associate Director, Center for Molecular Medicine and Genetics
Elliman Building, Rm 2148
421 E. Canfield Avenue
Detroit, MI 48201
313-577-9401
agow@med.wayne.edu

Education

Queensland University, Australia, PhD, 1990

Research Focus

Role of the unfolded protein response in neurodegenerative diseases; molecular characterization and regulation of axoglial junction assembly in CNS myelin; molecular characterization of the claudin family of integral membrane tight junction proteins during development in brain, testis, and inner ear using transgenic and homologous recombination in embryonic stem cells; learning and memory deficits in neurodegenerative disease.

Recent Publications

Laukka JJ, Stanley JA, Garbern JY, Trepanier A, Hobson G, Lafleur T, Gow A, Kamholz J. Neuroradiologic correlates of clinical disability and progression in the X-linked leukodystrophy Pelizaeus-Merzbacher disease. J Neurol Sci. 2013 Dec 15;335(1-2):75-81. doi: 10.1016/j.jns.2013.08.030. Epub 2013 Aug 30. PubMed PMID: 24139698.

Southwood CM, Fykkolodziej B, Dachet F, Gow A. Potential For Cell-mediated Immune Responses In Mouse Models Of Pelizaeus-Merzbacher Disease. Brain Sci. 2013 Dec 1;3(4):1417-1444. PubMed PMID: 24575297; PubMed Central PMCID: PMC3932547.

Maheras KJ, Gow A. Increased anesthesia time using 2,2,2-tribromoethanol-chloral hydrate with low impact on mouse psychoacoustics. J Neurosci Methods. 2013 Sep 30;219(1):61-9. doi: 10.1016/j.jneumeth.2013.07.004. Epub 2013 Jul 12. PubMed PMID: 23856212; PubMed Central PMCID: PMC3818901.

Southwood CM, Lipovich L, Gow A. Tissue-restricted transcription from a conserved intragenic CpG island in the Klf1 gene in mice. Biol Reprod. 2012 Nov 1;87(5):108. doi: 10.1095/biolreprod.112.099879. Print 2012 Nov. PubMed PMID: 22933519; PubMed Central PMCID: PMC3509778.

Saporta MA, Shy BR, Patzko A, Bai Y, Pennuto M, Ferri C, Tinelli E, Saveri P, Kirschner D, Crowther M, Southwood C, Wu X, Gow A, Feltri ML, Wrabetz L, Shy ME. MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot-Marie-Tooth disease type 1B. Brain. 2012 Jul;135(Pt 7):2032-47. doi: 10.1093/brain/aws140. Epub 2012 Jun 10. PubMed PMID: 22689911; PubMed Central PMCID: PMC3381724.