Hyunbae Kim, PhD

Education

• Soonchunhyang University, Korea, B.S., 1996
• Soonchunhyang University, Korea, M.S., 1998
• The Catholic University of Korea, Ph.D., 2005
• Wayne State University, Center for Molecular Medicine and Genetics, Postdoctoral Research Fellow, 2011-2016
• Wayne State University, Center for Molecular Medicine and Genetics, Research Scientist, 2016-2022

Research Focus

Dr. Kim works in the laboratory of Kezhong Zhang, PhD as an Assistant Professor (Research). He works on metabolic diseases resulting from disordered lipid homeostasis and transcriptional regulation.

Recent Publications

Zhu S, Song Z, Tapayan AS, Singh K, Wang KW, Chien Hagar HT, Zhang J, Kim H, Thepsuwan P, Kuo MH, Zhang K, Nguyen HM. "Effects of Heparan Sulfate Trisaccharide Containing Oleanolic Acid in Attenuating Hyperphosphorylated Tau-Induced Cell Dysfunction Associated with Alzheimer's Disease." Journal of Medicinal Chemistry. 02/13/2025;68(3):3356-3372. PubMed PMID: 39842821.

Kim H, Chen Q, Ju D, Purandare N, Chen X, Samavati L, Li L, Zhang R, Grossman LI, Zhang K. "ER-tethered stress sensor CREBH regulates mitochondrial unfolded protein response to maintain energy homeostasis."  Proc Natl Acad Sci U S A.12/03/2024. PubMed PMID: 39589874. doi: 10.1073/pnas.2410486121.

Wang JM, Li H, Xu L, Kim H, Qiu Y, Zhang K. "Boosting UPR transcriptional activator XBP1 accelerates acute wound healing." PNAS Nexus. 02/14/2023. PubMed PMID: 36959909.

Warrier M, Paules EM, Silva-Gomez J, Friday WB, Bramlett F, Kim H, Zhang K, Trujillo-Gonzalez  I. "Homocysteineinduced endoplasmic reticulum stress activates FGF21 and is associated with browning and atrophy of white adipose tissue in Bhmt knockout mice." Heliyon. 01/28/2023;9(2):e13216. PubMed PMID: 36755585.

Kim H, Song Z, Zhang R, Davies BSJ, Zhang K. "A hepatokine derived from the ER protein CREBH promotes triglyceride metabolism by stimulating lipoprotein lipase activity." Science signaling. 01/17/2023;16(768):eadd6702. PubMed PMID: 36649378.

Fu Z, Kim H, Morse PT, Lu MJ, Hüttemann M, Cambronne XA, Zhang K, Zhang R. "The mitochondrial NAD(+) transporter SLC25A51 is a fasting-induced gene affecting SIRT3 functions." Metabolism: clinical and experimental. 10/01/2022;135:155275. PubMed PMID: 35932995.

Kim H, Fu Z, Yang Z, Song Z, Shamsa EH, Yumnamcha T, Sun S, Liu W, Ibrahim AS, Qi NR, Zhang R, Zhang K. "The
mitochondrial NAD kinase functions as a major metabolic regulator upon increased energy demand." Molecular Metabolism. 10/01/2022;64:101562. PubMed PMID: 35944895.