Source: Michael R. McGowen, Lawrence I. Grossman and Derek E. Wildman “Dolphin genome provides evidence for adaptive evolution of nervous system genes and a molecular rate slowdown” Proc Biol Sci. 2012 Sep 22;279(1743):3643-51. Epub 2012 Jun 27.
Source: Ze Zheng, Xiaohua Xu, Xuebao Zhang, Aixia Wang, Chunbin Zhang,
Maik Hüttemann, Lawrence I. Grossman, Lung Chi Chen, Sanjay
Rajagopalan, Qinghua Sun, Kezhong Zhang. “Exposure to ambient particulate matter induces a NASH-like phenotype and impairs hepatic glucose metabolism in an animal model” J Hepatol. 2012 Aug 15. doi:pii: S0168-8278(12)00632-0. 10.1016/j.jhep.2012.08.009
Kraus P, Sivakamasundari V, Lim SL, Xing X, Lipovich L, Lufkin T. Making sense of Dlx1 antisense RNA. Dev Biol. 2013 Apr 15;376(2):224-35. doi: 10.1016/j.ydbio.2013.01.035. Epub 2013 Feb 8.
Saporta MAC, Shy BR, Patzko A, Bai Y, Pennuto M, Ferri C, Tinelli E,
Saveri P, Kirschner D, Crowther M, Southwood CM, Wu X, Gow A, Feltri
ML, Wrabetz L, Shy ME (2012) MpzR98C arrests Schwann cell development in a mouse model of early-onset Charcot-Marie-Tooth 1B Brain, 135:2032-2047. PMC3381724.
Recent Publications of Center Faculty Members
Kosir MA, Jia H, Ju D and Lipovich L (2013). Challenging paradigms: Long non-coding RNAs in breast ductal carcinoma in situ (DCIS). Front. Genet. 4:50. doi: 10.3389/fgene.2013.00050. More...
Kraus P, Sivakamasundari V, Lim SL, Xing X, Lipovich L, Lufkin T. Making sense of Dlx1 antisense RNA. Dev Biol. 2013 Apr 15;376(2):224-35. doi: 10.1016/j.ydbio.2013.01.035. Epub 2013 Feb 8. More...
Lipovich L, Tarca AL, Cai J, Jia H, Chugani HT, Sterner KN, Grossman
LI, Uddin M, Hof PR, Sherwood CC, Kuzawa CW, Goodman M, Wildman DE. Developmental Changes in the Transcriptome of Human Cerebral Cortex Tissue: Long Noncoding RNA Transcripts. Cereb. Cortex (2013) doi: 10.1093/cercor/bhs414. More...
Southwood CM, Lipovich L, Gow A (2012) Tissue-Restricted Transcription from a Conserved Intragenic CpG Island in the Klf1 Gene. Biol Reprod, doi: 10.1095/ biolreprod.112.099879. PMC3509778. More...
Hüttemann, M., Lee, I., Malek, M.H. (2012) (-)Epicatechin maintains endurance training adaptation in mice after 14 days of detraining. FASEB Journal, in press
Lipovich L, Johnson R, and Lin CY. MacroRNA underdogs in a microRNA world. (invited review article) Biochimica et Biophysica Acta 1799: 597-615, 2010. More....
Laing S, Wang G, Briazova T, Zhang C, Wang A, Zheng Z, Gow A, Chen AF, Rajagopalan S, Chen LC, Sun Q, Zhang K. Airborne particulate matter selectively activates endoplasmic reticulum stress response in the lung and liver tissues. Am J Physiol Cell Physiol 299(4):C736-749, 2010. More....
Xuebao Zhang, PhD
Research Associate, Laboratory of
Kezhong Zhang, PhD
"ERLIN2 associates with microtubule and regulates microtubule stability"
Thursday, May 30, 2013
12:00 p.m. – 1:00 p.m. in 2268 Scott Hall
Grunberger, M.D. has been elected vice president of the American
Association of Clinical Endocrinologists; he will also serve on the
association’s executive committee and the board of directors. Dr.
Grunberger is an affiliate member of the CMMG and former Director; in
2002 he founded the Grunberger Diabetes Institute in Bloomfield Hills,
Professor of Molecular Medicine and Genetics Leonard Lipovich, Ph.D.,
will present his lab’s work at the Cambridge Healthtech Institute’s
Bio-IT World Conference and Expo 2013, speaking as part of the
conference’s Track Nine, Drug Discovery and Informatics. Dr. Lipovich
will present “Beyond ENCODE: Placing Long Non-Coding RNA Genes into
Regulatory Networks for Therapeutics” in a 25-minute invited talk
Feldman, M.D., Ph.D., F.A.C.M.G., Professor of Molecular Medicine and
Genetics, has been elected president-elect of the American College of
Medical Genetics and Genomics. Dr. Feldman, director of Clinical
Genetic Services, will serve as president-elect through March 2015,
when he will become president of the college and hold that position
through 2017. More...
Samavati, M.D., F.C.C.P., Assistant Professor of Molecular Medicine and
Genetics and Internal Medicine, and Director of the WSU
Sarcoidosis/Interstitial Lung Disease Center, will use a $389,681 grant
for her study, “The Role and Regulation of MKP-1 in Sarcoidosis.” The
grant from the National Heart, Lung and Blood Institute is part of a
larger overall $1,906,944 NIH grant. More...
Interested in becoming a genetic counselor? Visit our open house to learn more about the Wayne State University Genetic Counseling Graduate Program.
research conducted by Center Assistant Professor Dr. Kezhong
Zhang, has discovered why people living in congested, urban
environments are at greater risk of developing metabolic disease.
The study focuses on air particulate matter, called PM 2.5, and
its affects on the liver. More information is available here.
State's Systems Biology of Epilepsy Project, led by Jeffrey
Loeb, MD, PhD, Associate Director of the Center for Molecular Medicine
and Genetics and Professor of Neurology, has released three new,
published studies that could have a major impact on the treatment of
epilepsy. Find out more here.
Kapatos, PhD, Professor of Molecular Medicine and Genetics and of
Pharmacology and Leonard Lipovich, PhD, Assistant Professor of
Molecular Medicine and Genetics and of Neurology have received the 2012
College Teaching Award in the School of Medicine.
PhD, Professor of Oncology and of Molecular Medicine and Genetics and
Derek Wildman, PhD, Associate Professor of Molecular Medicine and
Genetics and of Obstetrics and Gynecology have received the 2012
Research Excellence Award in the School of Medicine.
The Center would
like to welcome Dr. Samiran Ghosh. Dr. Ghosh, a biostatistician,
will be Assistant Professor of Family Medicine and Public Health
Sciences and of Molecular Medicine and Genetics. He comes from the
Stony Brook University School of Medicine in New York, where he worked
on several depression-based projects. He has also published a
book titled, "Bayesian Modeling in Bioinformatics."
The Center would like to introduce Erin Carmany,
MSCGC, who will be Assistant Professor of Molecular Medicine and
Genetics as well as Associate Director of the Genetic Counseling
graduate program. Ms. Carmany has served in the graduate program
since 2005 as a clinical instructor.
Dr. Leonard Lipovich,
Assistant Professor of Genetics and Molecular Medicine and of
Neurology, is determined to prove genetic material once seen as "junk"
to be of clinical value. Dr. Lipovich's lab has already
contributed several articles to the Encyclopedia of DNA (ENCODE),
an international collaborative effort that is the follow-up to the
Human Genome Project. This work is putting Wayne State
University at the forefront of genome analysis, and bringing it
alongside high-profile researcher groups in the United States, and
The Center welcomes Dr. Roger Pique-Regi
as its newest faculty member. Dr. Pique-Regi is the new
Assistant Professor of Molecular Medicine and Genetics and also with
the Department of Clinical and Translational Sciences. His lab
focuses on the topic of genetic instability, specifically finding the
DNA sequences responcible for gene expression and how genetic
instability can lead to disease. His lab also distributes two
software packages, CENTIPEDE and GADA, programs used for genetic
Dr. Maik Hüttemann,
who is Associate Professor of Molecular Medicine and Genetics and also
of Biochemistry and Molecular Biology, has been selected to receive a
2012 President's Award for Excellence in Teaching. Dr. Hüttemann
will be presented with the award at the Wayne State University Academic
Recognition Ceremony held April 26 at the McGregor Memorial Conference Center, where he will receive a citation and a cash award of $2,500.
Dr. Jeffrey A. Loeb,
Professor of Neurology and of Molecular Medicine and Genetics, and
Associate Director of the Center, has been selected to receive the 2012
Charles H. Gershenson Distinguished Faculty Fellowship. Dr. Loeb
will receive the Fellowship on July 1st, which includes a total of $13,000 in funds for the next two years.
Monica Uddin, PhD, Assistant
Professor of Molecular Medicine and Genetics and of Psychiatry and
Behavioral Neurosciences, has been awarded the 2012 Eli Robins, Samuel
Guze award for early career promise by the American Psychopathological
Association. More... News Archive