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Quick Look
• Graduated with a MS from Shanghai Second Medical University
• Graduated with a MD from Xinxiang Medical College
• Currently a fifth-year student in the PhD program
My interest in the program in the Center for Molecular Medicine and Genetics at Wayne State University stems from its incorporation of basic research in the fields of cellular/molecular biology and genetics into the advanced study of human diseases, offering and highlighting opportunities for translational medical research. This allows its individual members to acquire expertise in specific disciples within the field of modern biology, which can then be applied to particular problems facing the medical world. My area of concentration is hematology and cardiology, exploring the nature of vasculature, hematopoietic cells, cross-talk between the two systems and relevant diseases. Ultimately, I aim to investigate how the loss of transgelin alters the arterial remodeling process on the transcription level and if Smad3 based transcription regulatory machinery controls elastin and collagen balance in the arterial wall.
Research Interests
Advisor: Dr. Li Li
Transcription regulation, extracellular matrix shift underlying initiation and degenerative progression of vascular diseases such as atherosclerosis, stenosis and aneurysms
1. Research on roles of transgelin, a smooth muscle gene, in arterial diseases based on a carotid injury model of knockout mice.
2. Research on the function of Smad3, a transcription factor, in arterial diseases based on an abdominal aortic aneurysm model of knockout mice.
Awards and Recognitions
2008 Member of American Society of Hematology (ASH)
2007-2008 University Thomas C. Rumble Fellowship
Selected Publications
1. Shen JB, Tang JY, Pan C, Chen J, Xue HL, Wang YP. Telomerase activity and clinical characteristics of acute leukemia in children. Academic Journal of Shanghai Second Medical University, 2004,24(5):340-342
2. Wong X, Deng XH, Ma JQ, Shen JB, Yu JM, Liang H. Effect of different T cell ratios between graft and receptor on GVHD during transplantation. Academic Journal of Shanghai Second Medical University, 2004,24(2):94-96
3. Shen JB, Tang JY, Zhao JC, Pan C, Chen J, Zhou X, Wang YP. Telomerase activity and its correlation with proliferative potential of bone marrow in aplastic anemia in children. Acta Haematol, 2002,107(4):208-212
4. Shen JB, Tang JY, Zhao JC, Pan C, Chen J, Zhou X, Wang YP. Initial research on telomerase activity in aplastic anemia. Zhonghua Xue Ye Xue Za Zhi, 2001,22(10):543-545
5. Shen JB, Tang JY. Telomere, telomerase and pediatric malignant tumors. Journal of Leukemia, 2000,9(1):55-57
6. Shen JB, Tang JY. INK4, INK4 genes and hematological malignancies. Zhonghua Xue Ye Xue Za Zhi, 2000,21(5):274-276
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