Francesca Luca, PhD

Francesca Luca, PhD
Assistant Professor of Molecular Medicine and Genetics and of Obstetrics and Gynecology
Scott Hall, Rm 3317
540 E. Canfield Avenue
Detroit, MI 48201
313-577-1152
fluca@wayne.edu

Education

University of Calabria, PhD, 2006

Research Focus

My lab is interested in understanding the genetic and molecular basis of inter-individual and inter-population differences in complex phenotypes. We combine evolutionary and functional genomics approaches to study intermediate phenotypes (e.g.: transcription factor binding, gene expression, protein secretion, etc.) and how they are affected by gene-environment interactions.

Recent Publications

(2013-2016)

Moyerbrailean G, Harvey C, Kalita C, Wen X, Luca F*, Pique-Regi R* (2016) Which genetic variants in DNase I sensitivity regions are functional? PLoS Genetics 12(2): e1005875. doi:10.1371/journal.pgen.1005875. *Corresponding authors.

G. Moyerbrailean, O. Davis, C. Harvey, D. Watza, X. Wen, R. Pique-Regi*, F. Luca*. (2015) A high-throughput RNA-seq approach to profile transcriptional responses. Sci Rep, 29;5:14976. doi: 10.1038/srep14976. *Corresponding authors.

Wen X, Luca F, Pique-Regi R (2015) Cross-Population Joint Analysis of eQTLs: Fine Mapping and Functional Annotation. PLoS Genet 11(4): e1005176. doi:10.1371/journal.pgen.1005176

Chris Harvey, Gregory A Moyebrailean, Omar Davis, Xiaoquan Wen, Francesca Luca*, Roger Pique-Regi* (2014) QuASAR: Quantitative Allele Specific Analysis of Reads. Bioinformatics. 2014 Dec 4. doi:10.1093/bioinformatics/btu802. *Corresponding authors

Luca F, Maranville JC, Richards AL, Witonsky DB, Stephens M, Di Rienzo A. Genetic, functional and molecular features of glucocorticoid receptor binding. PLoS One. 2013 Apr 30;8(4):e61654. doi: 10.1371/journal.pone.0061654. Print 2013. 

Luca F, Di Rienzo A. Allelic imbalance assays to quantify allele-specific gene expression and transcription factor binding. Methods Mol Biol. 2013;1015:201-11. doi: 10.1007/978-1-62703-435-7_13.