|Russell L. Finley, Jr., Ph.D.
Division Director of Basic Science Research
3212 Scott Hall
540 East Canfield
Detroit, MI 48201
|Professor (also with Biochemistry and Molecular Biology; Member, Karmanos Cancer Institute); Ph.D., SUNY Upstate Medical University, 1990. Regulatory networks that control cell proliferation; high throughput technologies to study gene and protein interaction networks.
Research in our laboratory follows two main themes. One is directed at understanding how regulatory networks control biological processes. Our approach is to identify and characterize networks of interacting genes and proteins using high throughput technologies, including the yeast two-hybrid system and RNAi screens. The interaction maps that we generate from these studies form the foundation for discovering and understanding cellular regulatory pathways. A second theme of our research is directed at understanding the molecular mechanisms that control cell division. For these studies we are using the genetically tractable model organism, Drosophila (the fruit fly). We are studying gene networks centered on two novel conserved cyclin proteins (named Cyclin Y and Cyclin J). Cyclin proteins are regulators of cyclin-dependent kinases (Cdks), which are highly conserved S/T protein kinases that control the cell division cycle in all eukaryotes. For more information see the Finley Lab website.
Liu, D., and Finley, Jr., R.L. Cyclin Y is a novel conserved cyclin essential for development in Drosophila. Genetics, 184: 1025-1035, 2010.
Murali, T., Pacifico, S., Yu, J., Guest, S., Roberts, G.G., and Finley, Jr., R.L. DroID 2011: A comprehensive, integrated resource for protein, transcription factor, RNA, and gene interactions for Drosophila. Nucleic Acids Research, Oct. 29, 2010.
Schwartz, A.S., Yu, J., Gardenour, K.R., Finley, Jr., R.L., and Ideker, T. Cost effective strategies for mapping the interactome. Nature Methods, 6: 55-61, 2009.
Yu, J., and Finley, Jr., R.L. Combining multiple positive training sets to generate confidence scores for protein-protein interactions. Bioinformatics, 25: 105-11, 2009.
Yu, J., Pacifico, S., Liu, G., and Finley, Jr., R.L. DroID: the Drosophila Interactions Database, a comprehensive resource for annotated gene and protein interactions. BMC Genomics, 9:461, pp1-9, (PMID: 18840285), 2008.
Parrish, J.R., Liu, G., Hines, J.A., Yu, J., Chan, J.E., Mangiola, B.A., Zhang, H., Pacifico, S., Fotouhi, F., DiRita, V.J., Ideker, T., Andrews, P., and Finley, Jr., R.L. A proteome-wide protein interaction map for Campylobacter jejuni. Genome Biology, 8(7) R130.1-19, 2007.
Pacifico, S., Liu, G., Guest, S., Parrish, J.R., Fotouhi, F., and Finley, Jr., R.L. A database and tool, IM Browser, for exploring and integrating emerging gene and protein interaction data for Drosophila. BMC Bioinformatics 7, 195, 2006.
Parrish, J.R., Limjindaporn, T., Hines, J.A., Liu, J., Liu, G., Finley, Jr., R.L. High-throughput cloning of Campylobacter jejuni ORFs by in vivo recombination in Escherichia coli . Journal of Proteome Research, 3, 582-586, 2004.
Zhong, J., Zhang, H.,
Giot, L., Bader, J. S. , Brouwer, C., Chaudhuri, A., Kuang, B., Li, Y., Hao, Y. L., Ooi, C.E., Godwin, B., Vitols, E., Govindan, V., Pochart, P., Machineni, H., Welsh, M., Kong, Y., Zerhusen, B., Malcolm, R., Varrone, Z., Collis, A. Minto, M., Burgess, S., McDaniel, L., Stimpson, E., Spriggs, F., Williams, J., Neurath, K., Ioime, N., Agee, M., Voss, E., Furtak, K., Renzulli, R., Aanensen, N., Carrolla, S., Bickelhaupt, E., Lazovatsk, Y., DaSilva, A., Zhong, J., Stanyon, C.A., Finley, Jr., R.L., White, K.P., Braverman, M., Jarvie, T., Gold, S., Leach, M., Knight, J., Shimkets, R.A, McKenna, M.P., Rothberg, J.M., Chant J. A. A Genome-Scale Protein Interaction Map of Drosophila melanogaster. Science, 203, 1727-1736, 2003.
Regulated expression of proteins in yeast using the MAL61-62 promotor and mating scheme to increase dynamic range. 2002. Russell L. Finley Jr., Huamei Zhang, Jinhui Zhong, and Clement Stanyon. Gene. Volume 285, Issues 1-2, 20 February 2002, Pages 49-57.
A role for Cyclin J in the rapid nuclear division cycles of early Drosophila embryogenesis. 2000. M.G. Kolonin and R.L. Finley Jr. Developmental Biology 227, 661-672. [Full text]
Progress and potential of Drosophila protein interaction maps. 2000.
Kolonin, M.G., and Finley, Jr., R.L. Targeting cyclin-dependent kinases in Drosophila with peptide aptamers. Proc. Natl. Acad. Sci. U.S.A. 95:14266-14271, 1998.